Scientist II, Process Sciences

Company Details

Thermo Fisher Scientific

Work Location: San Francisco, CA

  • This position is ONLY available at the San Francisco, CA site

Group: Pharma Services Group

Division: Drug Substance

Business Unit: Biologics Business Unit Support

Thermo Fisher Scientific is making a significant investment in the dynamic and rapidly growing Cell Therapy space. Our Cell Therapy organization within the Pharma Services Group, is one of the fastest growing areas of Thermo Fisher Scientific. In the Cell Therapy group, we focus on providing development and clinical scale services for gene and non-gene modified cell processing for a variety of unmet medical needs. That being said, we have begun to build and operate a 44,000-square-foot, state-of-the-art cell therapy collaboration center on the UCSF Mission Bay campus. Expected to open in late 2022, the facility will serve as a central location where customers and UCSF researchers will have access to Thermo Fisher Scientific’s broad portfolio of solutions and clinical and commercial cGMP cell therapy manufacturing services, along with associated technology development support to UCSF and other partners. In the Cell Therapy group, we focus on providing development and clinical scale services for gene and non-gene modified cell processing for a variety of unmet medical needs.

How will you make an impact?

With guidance, you will apply technical skills to conduct experiments and studies to support our clients’ cell therapy needs and to assist in meeting the goals of the Cell Therapy group. Your experience and understanding of analytical design and development to establish new analytical methods and standard procedures for cell therapy product characterization will be utilized for collaborative planning, executing, and troubleshooting experiments, and assisting with other lab activities.

What will you do?

  • Carry out process development and optimization activities associated with autologous and allogeneic cell therapy workflows with the aim to improve costs, speed, and quality of the product
  • Work with blood cells or stem cells and routinely perform cell selection and activation, engineering (viral and non-viral), expansion, and cryopreservation
  • Design experiments, analyze data and present data to internal and external collaborators or customers
  • Participate in customer core teams as the technical lead for that project
  • Manage all project-related activities including the availability and suitability of materials and equipment to execute their assignments; coordinating hand-off of samples for downstream process and/or testing; Maintain accurate and detailed laboratory notes
  • Contribute to the development of closed automated platforms that will be used for cell therapy manufacturing
  • Work closely with clients for technology transfer activities, and with MS&T and Operations teams to transfer optimized process for clinical manufacturing and play an important role in to trouble-shooting process challenges.


How will you get here?


Education

  • BS or MS in biological sciences or engineering discipline; Equivalent combinations of education, training, and relevant work experience may be considered


Experience

  • 3+ years of relevant cGMP experience in a manufacturing pharmaceutical/biotech environment or related areas
  • Cell therapy automation technologies, closed system culture vessels, cell washers, cell separation technologies for autologous/allogenic product manipulation
  • Experience in process development or manufacturing setting is highly desired
  • Aseptic cell culture processing (T cells, NK cells, CAR-T, or Stem Cells) in ISO 5 biosafety cabinets while using universal precautions for handling of human-derived materials preferred
  • Experience in viral or non-viral genetic modification is preferred


Knowledge, Skills, Abilities

  • Understanding ‘why’ and not just the ‘how’ of processes and practices
  • Ability to drive safety, quality, functional, technical and operational excellence
  • Ability to work within cross functional teams and provide governance on project teams
  • Working knowledge of cGMP practices
  • Cell culture and aseptic techniques
  • Effective written, interpersonal, and presentation skills.
  • Ability to travel up to 20%
  • Excellent MS Office skills

Our global team of more than 100,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit www.thermofisher.com.

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

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